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ADVANTUS

FDA Application Number: 141-435

Based on the FDA Center for Veterinary Medicine data from May 2015 to December 2025: Of 33 reported animal deaths involving ADVANTUS, 22 occurred when ADVANTUS was the only drug administered - representing 67% of all fatalities.

67%
SINGLE-DRUG FATALITIES
ADVANTUS ONLY
1,947
TOTAL ANIMALS REPORTED
33
TOTAL FATALITIES
22
SINGLE-DRUG FATALITIES

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Top 3 Reported Reactions

Lack of Efficacy (Ectoparasite) - Flea
Pruritus
Lethargy (See Also Central Nervous System Depression in Neurological)

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SafeVetMeds equips users with the intelligence tools to ask better questions about veterinary drug safety. Powered by 100 million FDA adverse event data points, it delivers advanced safety insights, cross-drug comparisons, and real-world FDA data that is easy to search and simple to understand. The first platform of its kind now available to protect animals.

All data is sourced from the FDA Center for Veterinary Medicine adverse event reports submitted voluntarily by veterinarians, pet owners, and drug manufacturers. This information has not been independently verified and does not establish that any drug caused the reported outcomes. These reports reflect what was submitted to the FDA, not confirmed cause-and-effect relationships or actual risk rates. Reporting rates may vary by drug, manufacturer, and time period, and may be delayed up to 6 months. The percentage shown represents proportions within the reported dataset and does not indicate risk probability or safety ratings. SafeVetMeds is a 501(c)(3) nonprofit providing data transparency infrastructure and does not provide veterinary medical advice, diagnostic services, or legal counsel. For medical decisions regarding your animal, consult a licensed veterinarian. For legal questions, consult an attorney. This data should be considered as one factor among many in medical decision-making, not as definitive evidence of drug safety or danger.